Brain Fog and Your Immune System: What’s the Connection?

brain-fogStudies show that improving your immune system health may help treat brain fog symptoms.

Life throws enough curve balls to keep most people on their toes, but add brain fog and fatigue to the mix and daily challenges can become overwhelming.

What Cause Brain Fog?

There are several known causes of brain fog. According to Natural Solutions Magazine, February 24, 2009, five major causes are:

  • Stress. Chronic stress overstimulates the brain. Turning down the volume helps repair damage done to brain and nerve cells.
  • Fibromyalgia and chronic fatigue syndrome. Both of these are relatively recently recognized disorders that can cause impaired mental function. Magnesium might alleviate symptoms of both disorders.[i] Light to moderate exercise can boost the immune system and improve mood and sleep. Brain fog is also a hallmark symptom of Hepatitis C.
  • Fatigue.  As obvious as it sounds, tiredness and fatigue affects the gray matter. Lack of sleep can cause symptoms mimicking mental illness. We need from seven to nine hours of sleep per night—and quality counts. Don’t check email or do work right before going to bed. Avoid drinking caffeinated drinks late in the day. Practice calming techniques, such as meditation or deep breathing.
  • Nutrient deficiencies. Your brain is cranking through nutrients at a furious pace. Make sure a steady supply is at hand. Vitamins C and E have been shown to delay the onset of Alzheimer’s disease. The B vitamins can help improve memory. Zinc, Co-Q10, and essential fatty acids also help maintain healthy brain function.[ii]
  • Depression. Almost 10 percent of Americans suffer from depression, which can cause difficulty concentrating, remembering, and making decisions .[iii]

Neurotransmitter-boosting supplements, such as SAMe and 5-HTP help lift levels of dopamine and serotonin. St. John’s Wort may be a great option for minor depression.[iv] “For many,  brain fog can be severe and can have just as big an impact on their lives as pain or fatigue. In fact, some people say brain fog is more of a disability than their physical symptoms.”[v]

Brain Fog Symptoms: What are They?

Symptoms of brain fog can range from mild to severe, and frequently vary from day to day and not everyone has all of them. Brain fog symptoms include:

  • Word use and recall: Difficulty recalling known words, use of incorrect words, slow recall of names.
  • Short-term memory problems: Forgetfulness, inability to remember what’s read or heard.
  • Directional disorientation: Not recognizing familiar surroundings, easily becoming lost, having trouble recalling where things are.
  • Multitasking difficulties: Inability to pay attention to more than one thing, forgetfulness of original task when distracted.
  • Confusion and trouble concentrating: Trouble processing information easily distracted.
  • Math/number difficulties: Difficulty performing simple math, remembering sequences, transposing numbers, trouble remembering numbers.[vi]

Some people may also have other types of cognitive dysfunction.

Treating Brain Fog

Supplements are a common choice. Some doctors and people with these conditions say they’ve seen supplements help with cognitive function. Common brain-fog supplements include:

  • 5-HTP
  • B vitamins
  • Carnitine
  • Choline
  • Omega-3 (Fish Oil)
  • Rhodiola
  • St. John’s Wort
  • SAM-e
  • Theanine

Some doctors recommend making changes to your diet to include “brain-friendly” foods to boost overall brain health, which include:

  • Fish (Omega-3)
  • Canola or walnut oil (Omega-3)
  • Eggs (Choline)
  • Fruits & vegetables
  • Carbohydrates

Research shows that engaging in moderate exercise can also help improve cognitive function and contribute to better brain health.

Brain Fog and Hepatitis C

“Where are my keys?” What did I do with that book?” What time was I supposed to meet John?” Almost everyone – including people living with hepatitis C – forgets where they place things or has missed a meeting because they forgot the day or time of the appointment,” writes Alan Franciscus, Editor-in-Chief of hvcadvocate.org

Mr. Franciscus adds that the exact cause of brain fog in people with hepatitis C is poorly understood but there have been some recent studies that may explain the higher incidence of brain fog in the hepatitis C population. “One study found that since the hepatitis C virus crosses the blood-brain barrier there is some low level inflammation in the brain that would affect cognitive function.

A study in 2010 found that the hepatitis C virus destroys brain neurons and inhibits the removal of debris from the brain. Other experts speculate that the cause of brain fog may be due to the fact that the immune system is overstimulated trying to fight the hepatitis C virus. This process involves the immune system’s activation of the body’s innate defense system that produces killer cells, and a certain protein called interferon. The result of the natural production of interferon is that the body goes into an attack mode and this process produces side effects such as fatigue, muscle and joint pain as well as general cognitive dysfunction – this is the same process that occurs when someone catches the common cold or the flu.”[vii]

“Brain fog is different than the gradual memory loss that comes with aging – it is a sign of another underlying problem that may involve the immune system,” says Dr. Roger Mazlen M.D. of Long Island, N.Y. “Whether it appears gradually or suddenly, see a doctor to try to determine if there is an immunity or disease causing the symptom. Try to find relief through natural supplementation, if possible,” he said.


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Sources Cited in this Article

Natural Solutions magazine, February 24, 2009

Caregivers and Their Immune System

A Del-Immune V® customer recently sent an interesting article to us from the Wall StreetJournal of, July 1, 2003, titled “Elderly Caregivers Face Stress Toll.” This has become an important issue because we now live longer and have a growing population of seniors. This aging population, combined with current economics, is forcing more and more home care.

Medicare estimates that by 2020, 12 million older Americans will need long-term health care. For 70 percent of them, friends and family will serve as the primary caregivers.1

Supporting the caregiver is a relatively new area of study and is a matter of great concern within the healthcare system. Too often caregivers neglect their own health and well-being, putting their needs on the back burner at a time when they are facing unusual stress levels. One result of heightened stress can be the stimulation of one of the “super highways” within the immune system; Interleukin 6 (IL-6).

Within the immune system there are more than 30 superhighways or Interleukins. Each one has a specific area of activity. In a balanced, healthy immune system, IL-6 activates an inflammatory response that protects our body against foreign invaders. This super-highway is activated in clinical situations that include infection, burns, trauma, and neoplasia (exposure to cancer cells).2

Excessive, sustained or abnormal psychological stress appears to release increased levels of IL-6. The effects of the increased amounts of IL-6 in these situations relates to a large number of clinical conditions that are cited in the medical literature. Two examples are depression3and

autoimmune disease.4 Patients with rheumatoid arthritis typically have elevated levels of IL-6 in their synovial tissue (the tissue between joints).

Dysregulation of IL-6 cytokine (like a switch) signaling contributes to the acute and chronic stages of several diseases such as rheumatoid arthritis, inflammatory bowel disease, osteoporosis, multiple sclerosis, and various types of cancer (e.g. multiple myeloma and prostate cancer).5

A study from 2003, conducted by the National Alliance for Caretaking and AARP, found that stress of care giving for persons with dementia has been shown to impact a person’s immune system for up to three years after care giving ends, thus increasing their chances of the caretaker developing a chronic illness themselves. “Twenty-three percent of family caregivers caring for loved ones for five years or more report their health was fair or poor.”6

 

Taking care of you

Care giving for another person can be an exhausting job. Caregivers may sacrifice leisure time, vacations and privacy. Too often, caregivers neglect their own health and well being due to the overwhelming time and cost of scheduling outside help, educating temporary caregivers, etc.

According to a 2006 study, “72% of family caregivers report not going to the doctor as often as they should and 55% say they skip doctor appointments for themselves. 63% of caregivers report having poor eating habits than non-caregivers and 58% indicate worse exercise habits than before care giving responsibilities.”7

 

Where does Del-Immune V® fit into this picture?

Research from the Institute of Microbiology in Kiev, Ukraine demonstrated that Del-Immune V® stimulates the production of interferons, specifically interferons alpha, beta, gamma, and Tumor Necrosis Factor alpha. The interferons are critical to our health because they attack foreign bacteria, viruses, yeasts, and cancers. Laboratory-manufactured interferons are used to treat Hepatitis C.8

Interferon gamma plays a role in modulating, or controlling the production of IL-6. By modulating the IL-6 “superhighway,” it is believed the excessive inflammatory response caused by stress is reduced.

Anecdotal reports from caregivers taking Del-Immune V® state reduced problems with winter germs, an increase in their energy levels, and generally feeling good in spite of the daily stress of being a caregiver.

1 The Cost of Caring; The Rotarian, Sept. 2011. http://www.bio.davidson.edu/Courses/Immunology/Students/Spring2003/Sole/myfavprotien.htm

2 The Effects of Psychological Stress on Plasma Interleukin-6 Activity in Rats. Physiology &Behavior, Vol. 47, pp. 957-961, 1990.

3 Association of Depression with C-Reactive Protein, IL-1 and IL-6: Meta-Analysis. http://www.psychosomaticmedicine.org/content/7/2/171.abstract

4 Principles of Interleukin (IL)-6-type cytokine signaling and its regulation. Biochem J. 2003, Aug 15; 374 (Pt 1)-20.

5 http://www.nfcacares.org/who_are_family_caregivers/care_giving_statstics.cfm

6 Drs. Janice-Kiecolt Glaser and Ronald Glaser, Proceedings of the National Academy of Sciences, June 30, 2003. Caregiving in the United States; National Alliance for Caregiving in Collaboration with AARP.

7 Drs. Janice-Kiecolt Glaser and Ronald Glaser, Proceedings of the National Academy of Sciences, June 30, 2003. Caregiving in the United States; National Alliance for Caregiving in Collaboration with AARP.

8 Study of the Interferonogenous Activity of the New Probiotic Formulation Del-Immune V®. Immunology and Allergy, 2008, 2, pp. 16-23 (Ukraine)

Del-Immune V and Lyme Disease

Lyme disease appears to be a growing issue, not just in the U.S. but in Europe as well. We have received this letter from Dr. Richard Schneider of Zurich, Switzerland, and wanted to share it with our customers.

“I thank you for publishing information on Lyme disease and Del-Immune V® in your newsletter. I have now nearly concluded my case of Lyme disease.Tthe young lady from Scotland who comes to see me every other month can now be considered healed, I think.

“After about eight years of unsuccessful treatment attempts, she is full of energy, has a bright smile on her face because of all the things she can do again, and of course I am very happy, too.

“Here are my observations: Del-Immune V® and Delpro® alone do not do it. It needs some additional specific medications to kill the bugs and to detox. I have used the homeopathic form of Aurum Arsenicoum and later on Spiro from the Rainforest group. It also needs, at least in those longstanding chronic cases as this one, the extra time and sympathy from the treating doctor. Because the way to good health is not a straight one, there are ups and downs along the way – and in these cases it helps a patient a great deal if he or she can call the doctor and receive advice and also mental support. I hope this serves other medical people.”

– Dr. Richard Schneider, Zurich, Switzerland

Dr. Schneider makes an excellent point – that Del-Immune V® alone is not a “cure” for Lyme. Different Lyme patients need different therapies to manage the disease. Clearly, Dr. Schneider found a treatment program that worked for this patient. It may work for others as well. One of the most important things Lyme patients can do is to find a “Lyme literate” doctor to work with.

Sincerely,

John Sichel, RPh
President, Pure Researach Products LLC

Try our products today by ordering from our convenient online store.

Seasonal Flu or Just a Cold?

At Pure Research Products, our focus is on providing immediate immune system support to minimize problems with seasonal germs. Whether it’s a cold or the flu, when we get sick, we generally aren’t interested in why our immune system failed to protect us. We simply want the chills, aches, lingering cough and fever to go away. Missing work and other activities is always an inconvenience and sometimes it’s also expensive and debilitating.

The Centers for Disease Control (CDC) tracks the flu each year and provides regular reports posted on the Internet (www.cdc.gov). Sometimes it can be difficult to distinguish between the flu and a cold, but the CDC provides useful guidelines to help determine what ails us.

Information from the Centers for Disease Control

Q: What is the difference between a cold and the flu?

A: The flu and the common cold are both respiratory illnesses but they are caused by different viruses. Because these illnesses often have similar symptoms, it can be difficult to tell the difference between them based on symptoms alone.

In general, the flu is worse than the common cold, and symptoms such as fever, body aches, extreme tiredness and dry cough are more common and intense.

Colds are usually milder than the flu. People with colds are more likely to have a runny or stuffy nose. Colds generally do not result in serious health problems, such as pneumonia, bacterial infections or hospitalizations.

Special tests can be done to identify the influenza virus, but they usually must be done within the first few days of illness to return the most accurate results. Since most of us are unlikely to request such a test, or even see a doctor, when we first become ill, it can be helpful to understand the differences between these two illnesses.

Symptoms of the flu include:

  • Fever (usually high)
  • Headache, often severe
  • Extreme tiredness
  • Dry cough
  • Sore throat
  • Runny or stuffy nose
  • Muscle aches

Symptoms of the common cold include:

  • Usually no fever
  • Possible mild headache
  • Stuffy or runny nose and watery eyes
  • Sneezing
  • Sore throat
  • Coughing
  • Possible mild body aches

The primary differences involve fever (not usually present with a cold) and severity of symptoms such as fatigue and achiness. Stomach symptoms, such as nausea, vomiting and diarrhea also can occur with the flu but are more common in children than adults.

Is there any protection against the myriad of viruses responsible for seasonal infections, whether it’s a cold or the flu? Yes! Start with hand washing, plenty of sleep, adequate fluid intake (the immune system works best when hydrated), good nutrition, and covering a sneeze with a tissue or the crook of an elbow.

At Pure Research Products, we suggest that one or two Del-Immune V™ capsules per day generally help support the body’s immune system as it works to protect the body against germs and help you fight influenza. Stock up today at our online store.

Understanding Probiotics and Their Possible Health Benefits to Our Diets

Probiotics are defined by the FAO/World Health Organization as “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host.” (- Report of the Joint Food and Agriculture Organization of the Unitd Nations and World Health Organization for the Evaluation of Probiotics in Food.”)

The gastrointestinal (GI) tract naturally contains thousands of species of bacteria. These bacterial biochemical functions in the GI track are considered by many scientists and clinicians to be the next frontier in human biology. Possible health benefits of adding probiotics to our diet include:

  • Fewer gastrointestinal disorders
  • Lower incidence of diarrheal diseases
  • Enhanced lactose tolerance
  • Fewer vaginal and urinary tract infections
  • Modulation of the immune system
  • Enhanced calcium adsorption

Digestive, or “gut” health ranked first among the “10 Key Trends in Food, Nutrition and Health in 2008.” The focus on intestinal health research is indicated by more than 50 projects funded by the National Institutes for Health between 2006 and 2008. And that number grows today. The longstanding idea that 70% of the body’s immune response and activity occurs in the gut is being confirmed with extensive and ongoing research.

During the cough, cold and flu season, it can be important to consider the use of probiotic products to support the intestine during and/or after antibiotic therapy. Delpro® capsules can be taken one hour before or one hour after taking an antibiotic to minimize a problem called “dysbacteriosis,” which has symptoms such as diarrhea that can be triggered by antibiotic therapy.

Delpro is a blend of five strains of “friendly” bacteris, known as “probiotics,” combined with 8 mg. of Del-Immune V. While Del-Immune V does not require refrigeration, Delpro should be stored in the refrigerator. Those who travel with Delpro can be assured that the product retains freshness for 30 days and longer without refrigeration, so it may be carried when refrigeration is not available.

Order Delpro and Del-Immune V from our online store today.

From the desk of John Sichel, RPh, PD – Promoting Healthy Living Naturally

When I became a pharmacist 50 years ago, I never imagined I would have the privilege of making a product like Del-Immune V available to the public. Del-Immune V has made a significant difference in the lives of thousands of people around the world, some people who were frustrated and losing hope of ever experiencing good health again.

The immune booster was discovered in Russia in 1980, and I stumbled across a sample of it in 1999. Today, U.S.-made Del-Immune V is 10 times more powerful and is being produced in Indianapolis. It has been studied and tested by American microbiologists and found to provide effective, reliable, safe and immediate results.

In August 2005, I discovered researchers in the Ukraine were using an older version of the lactobacillus cell wall fragments in an injectible form to serve an adjunctive treatment of breast cancer. The Russian and Ukrainian medical publications were reporting a 15 percent greater improvement using the combination of lactobacillus cell wall fragments and conventional therapies. Research showed that using an injection of the lactobacillus every three to five days blocked the cancer cells from becoming immune to the cancer treatment.

To see if the American version of oral Del-Immune V would have the same effect during cancer therapy, I sent the product to Kiev to be researched. I will update you on the results.

For now, though, make plans to get in good health. Del-Immune V could be your best bet in providing yourself with immediate immune system support and protecting your loved ones and even your family pet from viruses, infections and other ailments.

Promoting healthy living naturally,

John Sichel, President and CEO, Pure Research Products, LLC

Please visit our online store to make a purchase today!

Study on Immunomodulating Effects of Del-Immune V

STUDY OF INTERFERONOGENOUS ACTIVITY OF THE NEW PROBIOTIC FORMULATION DEL-IMMUNE V®

“The biochemical structure of Del-Immune V and preliminary experimental and clinical data indicate that Del-Immune V may be highly effective in infectious diseases of viral (flu, hepatitis C), bacterial (bronchitis), and fungal etiology, allergies of all severity levels, asthma, chronic fatigue, and fibromyalgia.1-6 The mechanism of such a wide scope of biological activity of the formulation is still unclear. The goal of our research, therefore, was to study the mechanisms of the immunomodulating effects of Del-Immune V and to describe its dose-dependent effects on production of immunoregulatory cytokines in vivo and in vitro.

“The last 5 years have been marked by increasingly active study of the mechanisms of theimmunobiological effects of probiotics and bacterial medications.7-16 As a result, bacterial medications such as liastenum (blasten), deodan, licopid, prodigiosanum, salmosanum, sodium nucleinate, MC (molecular composition – yeast DNA and Tilorone), biostim, BCG, rumurtide, ribomunyl, and lactolin are being used, in both trials and clinical practice, for different pathologies.1-4 The adjuvant effect of BCG and the immunomodulating activity of formulations containing derivatives of lactobacilli, such as liastenum (blasten, Lactobacillus delbrueckii) and deodan (Lactobacillus bulgaricus), have been associated with peptidoglycans and their structural components, muramyl dipeptides (MDP). The most active analog of MDP, MurNac-L-Ala-D-Glu-NH2, has demonstrated adjuvant and pleiotropic effects and is capable of inducing a number of cytokines: IL-1, tumor necrosis factor (TNF- α), IL-2, IL-6, IL-8, IL-12, and interferon gamma (IFN-γ).17-26 These cytokines in turn stimulate nonspecific cytotoxicity of normal and effector lymphocytes and natural killer cells (NK), and coordinate the body’s immune response, depending on the nature of the aggressive agent and the T-helper differentiation (Th1 or Th2).9-12

Read the full text in .PDF format here: STUDY OF INTERFERONOGENOUS ACTIVITY OF THE NEW PROBIOTIC FORMULATION DEL-IMMUNE V®

REFERENCES
1. Karsonova MI, Andronova TM, Pinegin BV, Khaitov RM. Immunostimulating activity of muramyl dipeptide and its derivatives. Journal of
    Microbiology, Moscow. 1999;3:104-110. (in Russian)
2. Vospyakov VG, Petrov LN, Kalinin IM, Grishnyakov SB, Rugal VI, Kravets VN, Gonchar VA, Mosienko VS, Shynkarenko LN. Glycopeptides
    from lactobacilli as regulators of hemopoiesis and immunity. HIV/AIDS and Related Problems. 2000;4(1):32. (in Russian)
3. Voloska O, Shynkarenko L, Todosiychuk T, Zarutska I, Zabolotna D. Selection of the excipients for ready-made clinic formulations based on
    the selection lactic acid bacilli strains. Odessa Medical Journal. 2006,5(97), pp.3-6, (in Ukrainian)
4. Shynkarenko L, Richy E, Zabolotny D, Dechtyarenko N, Sichel J. Medical experiences of using Del-Immune – lysate powder of probiotic
    cells for immediate immune system support. In Abstracts of International Congress “Probiotics, Prebiotics, Synbiotics and Functional Food:
    Scientific and Clinical       Aspects.” May 15-16, 2007; St.Petersburg, Russia, #270, p.A76.
5. Tymoshok N, Shynkarenko L, Sichel J, Pidgorskyy V, Spivak M. Probiotic formulation Del-Immune V in experimental herpetic infection in
    mice. Abstracts V International Conference “Bioresourses and viruses.” September 10-13, 2007; Fitosociocenter, Kiev, Ukraine, p.22.
6. Spivak NY, Pidgorskyy V, Timoshok N, Lasarenko L, Shynkarenko-Sichel L. Immune regulatory cytokines Del-Immune V® induction and its
    impact on cytotoxicity of natural killer cells. II European Conference on Probiotics and their Applications, Cracow, Oct.15-17, 2008.
    Conference publication, p. 21.
7. Shirinskii VS, Zhuk EA. Characteristics and clinical use of immunostimulants. Ter.Arkh.1990;62(12):125-32.
8. Mosienko VS, Mosienko MD, Savtsova ZD, et al. Blasten – new domestic immunomodulator of the biological origin. Magazine AMS
    Ukraine. 1999;5(1):79-86.
9. Drannik GM, Mosienko VS. Blasten – stimulator of production IL-1 on patients with chronic obstructive bronchitis. Galytsky Medical News.
    1998;5(3):34-42.
10. Timoshok NO. Antibacterial activity of interferon inductors of different origin. PhD Dissertation reference. 03.00.07.Microbiology. ?,
    2002;1-22.
11. Lammers KM, Brigidi P, Vitali B, et al. Immunomodulatory effects of probiotic bacteria DNA: IL-1 and IL-10 response in human peripheral
    blood mononuclear cells. FEMS Immunol Med Microbiol. 2003;38(2):165-72.
12. Kaliuzhin OV. Muramil peptide’s derivates in experiment and in clinic. Journal of Microbiology (Russia), 1998;1:104-8.
13. Bondarenko VM, Ubakova EI, Lavrova VA. Immunostimulating action of lactobacteria used as the basis of probiotic preparations. Zh
    Mikrobiol Epidemiol Immunobiol. 1998;5:107-12.
14. Erickson KL, Hubbard NE. Probiotic immunomodulation in health and disease. J Nutr. 2000;130(2S-Suppl):403S-9S.
15. Solis Pereyra B, Lemonnier D. Induction of human cytokines by bacteria used in dairy foods. Nutr Research. 1993;13:1127-40.
16. Iliev ID, Kitazawa H, Shimosato T, et al. Strong immunostimulation in murine immune cells by Lactobacillus rhamnosus GG DNA containing
     novel oligodeoxynucleotide pattern. Cell Microbiol. 2005;7930;403-414.
17. Drannik GI, Svidro OV, Kushko LJ, Mosienko VS. Clinical and immunological efficiency of blasten used in patients with bronchopulmonary
     pathology. Problems of Ecology and Medicine. 1998, vol.2, #1-2, pp.13-17. (in Russian)
18. Mosienko VS, Mosienko MD, Savtsova ZD, Danilenko VS, Volkova MU, Shynkarenko LN, Shcheglova NA, Vospyakov VG, Svidro OV, Menyok
    TA. Blasten— new domestic immunomodulator of the biological origin. Magazin of AMS of Ukraine.1999, vol.5, #1, pp.79-86. (in Ukrainian)
19. Zaykov SV, Shpilevaya SI. Prospects of the application of the immunomodulators of muramyl peptides line in oncology. Rational
    Pharmacology, 2007;3(04):56-59.
20. Zaykov SV, Plicanchuk OV. The dynamics of immunologic induced in patients with first diagnosed destructive lung tuberculosis using
    immunomodulator of muramyl peptide series. Tavricheskiy medico-biology news, vol.12, #1, pp.62-66.
21. Ellouz F, Adam A, Ciorbaru R, Lederer E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.
    Biocemical and Biophysical Research Communications. 1974;59(4):1317-1325.
22. Allison AC, Byars NE. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated
    immunity. J.Immunol Methods. 1986;95(2):157-168.
23. Imeri L,Bianchi S, Mancia M. Mutamyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis.
    Am J Physiol Regul Integr Comp Physiol 1997;273:R1663-1668.
24. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall
    Components by the Innate Immune System Occurs Via Toll-Like Receptor2 .The Journal of Immunology. 1999;163:1-5.
25. Matricardi PM, Bjorksten B, Bonini S, Bousquet J, Djukanovic R, Dreborg S, Gereda J, Malling H-J, Popov T, Raz E, Renz H. Microbial
    products in allergy prevention and therapy. Allergy, 2003; 58:461-471.
26. Galdeano CM, de LeBlanc AM, Vinderola G, Bonet ME, Perdogon G. Proposed model: mechanisms of immunomodulation induced by
    probiotic bacteria. Clinical and Vaccine Immunology. May 2007:485-492.

Radiation Exposure and the Immune System

Since the tragic March 11, 2011 Japanese earthquake, tsunami, and nuclear power plant accidents, several customers have asked, “Can Del-Immune V® help with radiation exposure?” We decided to look through our original Soviet and Ukrainian documentation, as we know the grandparent of Del-Immune V®, called Extrabiolate, was researched after the Chernobyl accident in 1986 at the State Cancer Hospital in St. Petersberg, Russia, according to Dr. Vasiliy Kravitz, M.D., PhD. The primary research was conducted by the Institute of Experimental Pathology, Onocology and Radiobiology, National Academy of Science, Kiev, Ukraine.

Ukrainian and Russian documentation of animal studies state that “Usage of the cell fragment material [grandparent of Del-Immune V®] leads to the reduction of mortality by as much as two times.” The animals had been exposed at the Chernobyl accident site via “external background radiation and also radiation (radio nucleotides) present in food and water.”

“Animal consumption of the cell fragments before radiation not only increased the rate of survival by twice, but also increased average life duration,” the study states.

This study of radiation and cell fragments, called ”extrabiolate,” the grandfather of what is now known as Del-Immune V®, and immune function is a small part of a large body of Russian/Soviet scientific research on lactobacillus cell fragments.

The Greenpeace Chernobyl Study

Greenpeace, founded in 1971, is an international non-profit organization dedicated to environmental protection. In 2006, Greenpeace released an exhaustive eight-year study on world-wide health issues after the Chernobyl accident titled, “The Chernobyl Catastrophe: Consequences on Human Health.” With over 50 accredited scientific contributors, the study compares the type and numbers of post-accident health issues against pre-accident data. Geographically, researchers found health impacts as far away as the British Isles.

The report states that the accident was, “The most significant and wide ranging technological catastrophe in the history of humankind. Twenty years later, several million people (by various estimates, from 5 to 8 million) still reside in areas that remain highly contaminated by Chernobyl’s radioactive pollution. The radiological (and hence health) consequences of this nuclear accident are expected to be experienced for years to come, since the half-life of the major (though far from the only) radioactive element released, caesium-137 (137Cs), is a little over 30 years.

“At least 14 other countries in Europe were contaminated by radiation above the limit used to define areas as “contaminated.” Lower, but nonetheless substantial quantities of radioactivity linked to the Chernobyl were detected all over the European continent, from Scandinavia to the Mediterranean, and in Asia.”1

Effects of radiation on the immune system

Our ten years of experience with Del-Immune V® has confirmed that the product provides immediate immune system support. The following information is intended to help answer customer questions regarding potential health and immune issues relating to the Chernobyl and Fukushima accidents.

There has been sixty years-worth of research and experience with radioactive substances; researchers worldwide strive to understand the impact of radiation on all forms of life. What is known is that high levels of radiation exposure are generally a death sentence, while lower degrees of exposure, i.e. small amounts of radiation in food, water and air bring less obvious issues and can affect health for many years after a nuclear incident.2

Scientific lessons were learned from the April 26, 1986 Chernobyl nuclear accident and the nuclear bombing of Japan in August 1945. Now, with the March 11, 2011 Fukushima nuclear accident in Japan, new concerns about radiation-linked health issues are emerging. We can look to the science already documented by researchers after the Chernobyl accident for a glimpse of the possible health implications of the Fukushima accident, specifically for the immune system.

Researchers now know that there are multiple levels of health issues and impacts on the immune system after radiation exposure. It is also known that in the early period following exposure, there is a significant outbreak of auto-immune disease, systemic bacterial infection and other types of infection. According to Dr. Luba Shynkarenko Sichel PhD, the cytokine Interleukin-2 (IL2), which functions like a master on-off switch in the immune system, is disrupted. “IL-2 is crucial for the generation of an effective immune response.”3 In other words, if the immune system is a highly organized army, IL-2 would be the supreme commander. When IL-2 is disrupted, other components of the immune system fall out of balance.

‘Immune cells are known to be vulnerable to radiation induced cell death, especially in the long-lived white blood cells responsible for adaptive (secondary) immunity. Other lethal damage occurs in the bone marrow stem cells, precursors of short-lived white blood cells as well as natural killer cells, both responsible for innate (primary) immunity.”4 In other words, damage to the bone marrow disrupts precursors to stem cells and natural killer cells that are responsible for neutralizing infectious disease.

The Greenpeace study also states that disruption of the immune system has a direct relationship to the incidence and severity of infectious disease. “Some of the statistics gathered post-Chernobyl suggested that radiation exposed-populations may be more vulnerable to infectious disease.”5

Post-radiation syndrome

After the Chernobyl accident, researchers observed a group of symptoms that became known as ‘Post-radiation Syndrome’ (PRS) When referenced to post-WWII data on radiation exposure in Japan, the same symptoms were also found in those populations.

According to Dr. Martin Pall of the School of Molecular Biosciences, Washington State University, “PRS has been most studied among those exposed to ionizing radiation after the Chernobyl nuclear accident with some additional studies of atom bomb survivors. The complex chronic symptoms have typically been found in persons both shortly after exposure and continuing for years after such exposure. Symptoms include fatigue, sleep and mood disturbances, impaired memory and concentration and muscle and/or joint pain. Symptoms also reported are persistent fatigue, irritability, headache, vertigo, pain in the chest area, emotional reactivity, lack of concentration and memory, cognitive deterioration, depression and sleep disorders.

“These symptoms and the chronic nature of the illness are quite similar to those described in a group of chronic multisystem illnesses including chronic fatigue syndrome (CFS, fibromyalgia (FM) and multiple chemical sensitivity CFS, FM and MCS have been linked to each other because they share a set of common symptoms.”6

Cancer and radiation

After radiation exposures the he body loses its ability to control the growth of cancer cells. “Today, it is clear that the pollution from Chernobyl has indeed caused increases in cancers. In patients from Belarus, for example, incidences of kidney, urinary/bladder and thyroid cancer were significantly higher for the period of 1993 to 2003 than in a comparable group.”7

After Chernobyl, thyroid cancer rates increased in the Czech Republic, Southern Germany, Armenia, Romania, Ukraine, Belarus, Greece and even as far away as Northern England.

“Thyroid cancer was significantly elevated in Northern England, particularly in Cumbria, the area that received the most fallout from the accident.”8

Simply put, radiation exposure is detrimental and disruptive to immune function, and the effects can continue over the long-term. “Immune system radiation effects are cumulative. All forms of radiation interfere with cellular activity and suppress immune system function,” says Immunesystemetc.com. The Greenpeace Chernobyl study also states that “Overall it appears that since 1986 in the former territories of the USSR, life expectancy has decreased, with increase in infant mortality and mortality rates in older age groups.”9

As we have said, Del-Immune V® is a broad-spectrum immune modulator that offers immediate immune support. Pure Research Products, via the Japanese Consulate in Denver, Colorado, has offered 200,000 doses of Del-Immune V® to help support the immune systems of workers and others in the vicinity of the Fukushima nuclear reactors. We are also working the International Rotary Club to assist with this proposal. We will report the results of our efforts in future newsletters and blog posts.

[1] Greenpeace, pg. 10
[2] http://www.greenpeace.org/raw/content/international/press/
reports/chernobylhealthreport.pdf
[3] http://www.hon.ch/Library/Theme/Allergy/Glossary/il2.html
[4] From the Radiation Effects Research Foundation,
A cooperative Japan-US Research Organization
(www.rerf.or.jp/radefx)
[5] Greenpeace pg. 16
[6] http://www.cfids-cab.org/rc/Pall.pdf ARTI
[7] Greenpeace pg. 12
[8] Greenpeace, pg. 136
[9] Greenpeace, pg. 24

Where and why does Del-Immune V® work?

Del-Immune V® research has been conducted at the Institute of Microbiology in Kiev, Ukraine by Dr. Nikoli Tymoshok, Professor and Head of the Department of Immunology. Professor Tymoshok’s paper, titled “The Interferogenous Activity of Del-Immune V®” was presented at the International Congress of Prebiotics and Probiotics in St. Petersburg, Russia. Two subsequent research reports have since been published on Del-Immune V® with the focus on interferon stimulation. So what are interferons and what is their job in the immune complex?

Interferons – The guards at the gate

When viruses infect human cells, a switch called a cytokine turns on and launches production of special proteins called interferons. These interferons have several important jobs to protect us from viruses and other infections. First, they interfere with the multiplication of viruses causing infection. Next, interferons quickly recruit help by sending signals to neighboring cells that aren’t infected, warning them to prepare for the viral infection.

Interferons also help make viruses more susceptible to killer white cells. In summary, the interferons kill viruses and also send a warning to alert healthy cells to an impending viral attack. While our immune system has hundreds of specialized components all communicating with each other, the interferons play a critical role in maintaining health.

There are several different kinds of interferons and, while research continues to define the roles of some, we will highlight four important types:

Interferon Alpha INF: Primarily involved with the innate, or primary immune system to respond to viral invaders. There are many different forms of interferon alpha INFs.

Interferon Beta IFN: Produced in cells that are different from interferon alpha. Their job is also to help kill viruses.

Interferon Gamma IFN: Involved with the immune response throughout our body and signals the rest of the system to prepare for a viral attack. The activity of interferon gamma also involves anti-tumor activity. IFN gamma is regarded as a key immune regulator and can act as a brake or an accelerator in the immune system.

TNF alpha: Tumor Necrosis Factor (TNF) interacts with tumor cells to trigger cell deaths in the tumor.

Following a complicated set of research experiments, Professor Tymshok concluded the following information about Del-Immune V®:

Del-Immune V® demonstrates a high level of interferon activity. Levels of interferon in laboratory animals increased two to three times higher than the control animals.
With oral administration of Del-Immune V®, there was an immediate immune response producing high levels of interferons eight hours after oral administration.
TNF increased 10 times higher than the control group with Del-Immune V®.
Del-Immune V® demonstrated a broad spectrum of immune modulation properties. This means it helps the immune system when help is needed and does not produce stimulation when not needed.
The bottom line is that Del-Immune V® has been shown to activate some of the most important components of the immune system to provide fast protection against viruses, bacteria, tumor cells and other foreign invaders.